Prof. Dr. H. Bäumler : +49 30 450 625131

Fr. Dr. R. Georgieva:  +49 30 450 525146

Promotionsthemen: Zur Zeit 13 laufende Arbeiten. 

Unsere Doktorandinnen und Doktoranden:

Mathis Dickel, Moritz Hackmann, Lara-Elena Heil Olaizola, Ijad Kao, Jakob Krauß, Maxine-Anna Müller-de Ahna, Jonathan Nimz, Pichayut Rerkshanandana, Bastian Rohlffs, Julie Sossah, Katrin Smuda, Axel Steffen, Xiaotong Zhao

Im Rahmen von Horizon 2020 war die AG Partner im EU-Projekt BIOCAPAN, in dem ein Prototyp zur Einkapselung und Implantation von Insulinzellen zur Therapie von Diabetes II entwickelt wurde. Mehr zu Biocapan ist zu finden unter https://cordis.europa.eu/project/id/646272/de 

In einem weiteren von der EU geförderten Marie-Curie Projekt "Oxigenated" werden Drugcarrier entwickelt, die zur photodynamischen Tumor-Therapie eingesetzt werden können. Mehr zu Oxigenated ist zu finden unter http://personal.cicbiomagune.es/smoya/oxigenated/home.html

In einem ZIM-Kooperationsprojekt mit Serana Europe GmbH und Biophyll GmbH werden qualifizierte und stabilisierte Hämoglobin-Enzym-Komplexlösungen als Medizinprodukt bzw. für pharmazeutische Anwendungen hergestellt. Weitere Informationen sind zu finden unter https://www.biophyll.com/

Im Rahmen des Sino-German rapid response funding call for COVID-19 arbeiten wir seit Oktober 2020 gemeinsam mit unserem Kooperationspartner, dem Institut für Bluttransfusion in Chengdu an der Entwicklung eines Virus-Scavengers.

• Charité und Berlin-Brandenburg Center for Regenerative Therapies (BCRT):
• Institut für Radiologie CVK, AG Prof. Patzeck - Institut für Vegetative Physiologie, AG  Prof. Dörner - Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, AG Prof. Pruß -  Institut für Transfusionsmedizin/ Gewebebank
• MPI für Kolloid- und Grenzflächenforschung, Potsdam-Golm
• Medizinische Hochschule Hannover, Institut für Transfusionsmedizin, Prof. Blaszyk
• Université Catholique de Louvain, Brüssel, Prof. Glinel
• CIC biomaGUNE, San Sebastian, Spanien , Prof. Moya
• Université Joseph Fourier, Grenoble, Frankreich. Prof. Lablanche
• Chulalongkorn University Bangkok, Thailand, Prof. Chanchai
• Chiang Mai University, Chiang Mai, Thailand, Prof. Tragoolpua
• Universidade de Brasília, Brasilia, Brasilien, Prof. Azevedo
• Universidad Nacional de San Martín, Buenos Aires, Argentinien, Prof. Galo und Prof. Simian

1. Georgieva R, Moya S, Leporatti S, Neu B, Bäumler H, Reichle C, Donath E, Möhwald H, Conductance and Capacitance of Polyelectrolyte and Lipid-Polyelectrolyte Composite Capsules measured by electrorotation. Langmuir 2000;16:7075-7081
2. Moya S, Donath E, Sokhorukov G, Auch M, Bäumler H, Lichtenfeld H, Möhwald H, Lipid coating on polyelectrolyte surface modified colloidal particles and polyelectrolyte capsules. Macromolecules 2000;33:4538-4545
3. Bäumler H, Artmann G, Voigt A, Mitlöhner A, Neu B, Kiesewetter H, Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. J. Microencapsulation 2000;17:651-655
4. Bäumler, H, Neu, B, Mitlöhner, R, Georgieva, R, Meiselman, H, Kiesewetter, H, Electrophoretic and aggregation behavior of bovine, horse and human red blood cells in plasma and in polymer solutions. Biorheology 2001;38:39-52
5. Neu B, Voigt A, Mitlöhner R, Leporatti S, Gao CY, Donath E, Kiesewetter H, Möhwald H, Meiselman H, Bäumler H, Biological cells as template for hollow microcapsules. J. Microencapsulation 2001;18:385-395
6. Büttnerova I, Bäumler H, Kern F, Radtke H, Volk H-D, Kiesewetter H, Döcke W-D, Release of WBC-derived IL-1 receptor antagonist into supernatants of RBCs: influence of storage time and filtration. Transfusion 2001;41:67-73
7. Voigt A, Buske N, Sukhorukov GB, Antipov AA, Leporatti S, Lichtenfeld H, Bäumler H, Donath E, Möhwald H, Novel polyelectrolyte multilayer micro- and nanocapsules as magnetic carriers. J. Magnetism and Magnetic Materials, 2001;225:59-66
8. Neu B, Armstrong JK, Fischer TC, Bäumler H, Meiselman HJ, Electrophoretic mobility of human red blood cells coated with poly(ethylene glycol). Biorheology 2001; 38:389-403
9. Neu B, R. Georgieva, H.J. Meiselman, H. Bäumler. Alpha- and beta-dispersion of fixed platelets: Comparison with a structured based theoretical approach. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2002; 196(1-3):27-35
10. Georgieva R, Moya S, Hin M, Mitlöhner R, Donath E, Kiesewetter H, Möhwald H, Bäumler H. Permeation of Macromolecules into Polyelectrolyte Microcapsules. Biomacromolecules 2002,3:517-524
11. Neu B, Meiselman H, Bäumler H. Electrophoretic mobility of human erythrocytes in the presence of poly(styrene sulfonate). Electrophoresis 2002; 23:2363-2368
12. Jovtchev S, Dzhenev I, Bäumler H, Stoeff S, Marinov M, Stoylov S. Factors determining the electro-optical behaviour of red blood cells. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2002; 209: 257-265
13. Donath E, Moya S, Neu B, Sukhorukov G, Georgieva R, Voigt A, Bäumler H, Kiesewetter H, Möhwald H. Hollow Polymer Shells from Biological Templates: Fabrication and Potential Applications. Chem. Eur. J 2002; 8:5481-5485
14. Moya S, Georgieva R, Bäumler H, Richter W, Donath E. Composite Lipid Polyelectrolyte Capsules Templated on Red Blood Cells - Fabrication and Structural Characterization. Med. Biol. Eng. Comput. 2003; 41: 504-508
15. Moya S, Richter W, Leporatti S, Bäumler H, Donath E. Freeze-Fracture Electron Microscopy of Lipid Membranes on Colloidal Polyelectrolyte Multilayer Coated Supports. Biomacromolecules 2003; 4: 808-814
16. Georgieva R, Moya S, E. Donath E, Bäumler H, Permeability and Conductivity of Red Blood Cell Templated polyelectrolyte Capsules Coated with Supplementary Layers, Langmuir, 2004; 20:1895-1900
17. Bäumler H, Kelemen C, Mitlöhner R, Georgieva R, Krabi A, Schäling S, Artmann G, Kiesewetter H. Micromechanical Properties of newly Developed Polyelectrolyte Microcapsules (PEMC). In: Artificial Oxygen Carrier, Kobayashi K, Tsuchida E, Horinouchi H (Eds.) Keio University International Symposium for Life Sciences and Medicine Vol. 12.Springer-Verlag Tokyo 2005, 205-216
18. Kreft O, Georgieva R, Bäumler H, Steup M, Müller-Röber B, Sukhorukov GB, Möhwald H. Red Blood Cell Templated Polyelectrolyte Capsules: A Novel Vehicle for the Stable Encapsulation of DNA and Proteins. Macomol. Rapid Commun.2006; 27:435-440
19. Brähler M, Georgieva R, Buske N, Müller A, Müller S, Pinkernelle J, Teichgräber U, Voigt A, Bäumler H, Magnetite – loaded carrier erythrocytes as contrast agent for magnetic resonance imaging. Nanoletters 2006; 6: 2505-2509
20. Bäumler H, Brähler M, Georgieva R, Müller A, et al. Natural carrier for nanoparticles - Targeted delivery of drugs. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 30 (8): 709-709 AUG 2007
21. Bäumler H, Brähler M, Georgieva R, et al. Artificial carrier for nanoparticles-targeted delivery of drugs. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 30 (8): 723-723 AUG 2007
22. Ivanov IT, Brähler M, Georgieva R, Bäumler H. Role of membrane proteins in thermal damage and necrosis of red blood cells THERMOCHIMICA ACTA 456 (1): 7-12 MAY 1 2007
23. Garbers E, Mitlöhner R, Georgieva R, Bäumler H. Activity of immobilized trypsin in the layer structure of polyelectrolyte microcapsules (PEMC). Macromol Biosci. 2007 Dec 6;7(12):1243-9.
24. Cicero AF, Nascetti S, López-Sabater MC, Elosua R, Salonen JT, Nyyssönen K, Poulsen HE, Zunft HJ, Kiesewetter H, de la Torre K, Covas MI, Kaikkonen J, Mursu J, Koenbick C, Bäumler H, Gaddi AV; EUROLIVE Study Group. Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE study. J Am Coll Nutr. 2008 Apr;27(2):314-20
25. Chanana M, Jahn S, Georgieva R, Lutz J, Bäumler H, Wang D. Fabrication of Colloidal Stable, Thermosensitive, and Biocompatible Magnetite Nanoparticles and Study of Their Reversible Agglomeration in Aqueous Milieu. Chem. Mater. 2009, 21, 1906–1914
26. Staedtke V, Brähler M, Müller A, Georgieva R, Bauer S, Sternberg N, Voigt A, Lemke A, Keck C, Möschwitzer J, Bäumler H. In vitro Inhibition of Fungal Activity by Macrophages Mediated Sequestration and Release of Encapsulated Amphotericin B - Nanosupension in Red Blood Cells.  Small, 2009, 6, 96-103
27. N. Sternberg, R. Georgieva, Z. Abdallah, A. Müller, H. Bäumler, Loaded red blood cells as natural micro carriers for drug delivery. In Proceedings of the 17^th International Workshop on Bioencapsulation, Groningen, Netherlands, 24 – 26 September 2009, P74, p.1-4.
28. Tölle, A, Abdallah Z, Jung K, Bäumler H. Measurement Conditions for Flow Cytometry Analyses of Cell Lines from Urological Carcinomas J Fluoresc (2010) 20:779–786, DOI 10.1007/s10895-010-0621-5
29. Stelter L, Pinkernelle JG, Michel R, Schwartländer R, Raschzok N, Morgul MH, Koch M, Denecke T, Ruf J, Bäumler H, Jordan A, Hamm B, Sauer IM, Teichgräber U. Modification of Aminosilanized Superparamagnetic Nanoparticles: Feasibility of Multimodal Detection Using 3T MRI, Small Animal PET, and Fluorescence. Mol Imaging Biol. 2010;12(1):25-34.
30. Bäumler H, Georgieva R. Coupled Enzyme Reactions in Multicompartment Microparticles Biomacromolecules 2010;11(6):1480-7
31. Moreno-Flores S, Georgieva R, Xiong Y, Melzak K, Bäumler H, Toca-Herrera J. Physical attachment of fluorescent protein particles to atomic force microscopy probes in aqueous media: Implications for surface pH, fluorescence, and mechanical properties studies. Microscopy Res. Techn. 73, 8, 746-751. Published Online: Dec 23,2009, 11:41AM DOI: 10.1002/ jemt.20816
32. Mak W, Georgieva R, Renneberg R, and Bäumler H. Protein Particles Formed by Protein Activation and Spontaneous Self-Assembly. Advanced Functional Materials 2010, 20, 4139–4144
33. Rodrigues J, Abramjuk C, Vásquez L, Gamboa N, Domínguez J, Nitzsche B, Höpfner M, Georgieva R, Bäumler H, Stephan C, Jung K, Lein M, Rabien A. New 4-Maleamic Acid and 4-Maleamide Peptidyl Chalcones as Potential Multitarget Drugs for Human Prostate Cancer. Pharm Res. 2010 Dec 24. [Epub ahead of print]PMID: 21184149 DOI: 10.1007/s11095-010-0347-8, 2011; 28,907-919
34. Andreas K, Zehbe R, Kazubek M, Grzeschik K, Sternberg N, Bäumler H, Schubert H, Sittinger M, Ringe J. Biodegradable insulin-loaded PLGA microspheres fabricated by three different emulsification techniques:Investigation for cartilage tissue engineering. Acta Biomater. 2010 Dec 16. [Epub ahead of print]2011; 7, 1485-1495
35. Delcea Mihaela, Sternberg Nadine, Yashchenok Alexey M, Georgieva Radostina, Bäumler Hans, Möhwald Helmuth, and Skirtach Andre G. Nanoplasmonics for Dual-Molecule Release through Nanopores in the Membrane of Red Blood Cells. ACS Nano, 2012, 6 (5), pp 4169–4180, Publication Date (Web): April 1, 2012 (Article) DOI: 10.1021/nn3006619
36. Sternberg, Nadine; Georgieva, Radostina; Duft, Karolin; Bäumler, Hans. Surface-modified loaded human red blood cells for targeting and delivery of drugs. Journal of Microencapsulation, Volume 29, Number 1, January 2012 , pp. 9-20(12)
37. N.Sternberg, K. Andreas, H. Bäumler, R. Georgieva Blood cells as carriers for magnetically targeted delivery of drugs. In: Magnetic Nanoparticles: From Fabrication to Clinical Applications. ISBN 9781439869321 EDITOR: Nguyen TK Thanh, University College London, UK 2012
38. Yu Xiong, Axel Steffen, Kristin Andreas, Susanne Müller, Nadine Sternberg, Radostina Georgieva, and Hans Bäumler. Hemoglobin-Based Oxygen Carrier Microparticles: Synthesis, Properties, and In Vitro and In Vivo Investigations. Biomacromolecules, 2012, 13 (10), pp 3292–3300 DOI: 10.1021/bm301085
39. Yu Xiong, Zhi Zhao Liu, Radostina Georgieva, Kathrin Smuda, Axel Steffen, Mauricio Sendeski, Andreas Voigt, Andreas Patzak, and Hans Bäumler. Nonvasoconstrictive Hemoglobin Particles as Oxygen Carriers ACS Nano, 2013, VOL. 7, NO. 9, 7454–7461
40. Michael J. Koziol, Torsten K. Sievers, Kathrin Smuda, Yu Xiong, Angelika Müller, Felix Wojcik, Axel Steffen, Margitta Dathe, Radostina Georgieva, Hans Bäumler. Kinetics and Efficiency of a Methyl-Carboxylated 5-Fluorouracil-Bovine Serum Albumin Adduct for Targeted Delivery Macromol. Biosci. 2013, DOI: 10.1002/mabi.201300363 Macromol. Biosci. 2014, 14, 428–439
41. Hans Bäumler, Yu Xiong, Zhi Zhao Liu, Andreas Patzak, and Radostina Georgieva. Novel Hemoglobin Particles—Promising New-Generation Hemoglobin-Based Oxygen Carriers. Artificial Organs 2014, (38):708-714doi:10.1111/aor.12331
42. Aitziber Eleta-Lopez, Juan Etxebarria, Niels-Christian Reichardt,,Radostina Georgieva , Hans Bäumler, José L. Toca-Herrera. On the molecular interaction between albumin and ibuprofen: An AFM and QCM-D study. Colloids and Surfaces B: Biointerfaces 134 (2015) 355–362
43. Severyukhina, A.N.; Petrova, N.V.; Smuda, K.; Terentyuk, G.S.; Klebtsov, B.N.; Georgieva, R.; Bäumler, H.; Gorin, D.A. Photosensitizer-loaded electrospun chitosan-based scaffolds for photodynamic therapy and tissue engineering. Colloids and Surfaces B: Biointerfaces 2016 144:57-64
44. Hans Bäumler, Laura Hamberger, Paul Zaslansky, Ulrich Kalus, RadostinaGeorgieva, Axel Pruss. Non-destructive mechanical testing of allograft bone-implants by analytic centrifu-gation. Experimental Mechanics 2016(56)1653–1660 doi:10.1007/s11340-016-0201-y
45. Lian Zhao, Waraporn Kaewprayoon, Hong Zhou, Radostina Georgieva, Hans Bäumler. RBC aggregation in dextran solutions can be measured by flow cytometry. Clin. Hemorheology 2017;65(1):93-101 DOI: 10.3233/CH-15121
46. Severyukhina, A.N., Petrova, N.V., Yashchenok, A.M., Bratashov, D.N., Smuda, K., Mamonova, I.A., Yurasov, N.A., Puchinyan, D.M., Georgieva, R., Bäumler, H., Lapanje, A., Gorin, D.A.: Light-induced antibacterial activity of electrospun chitosan-based material containing photosensitizer. Mat Sci Eng C-Bio S. 2017;70(Pt 1):311-6. DOI: 10.1016/j.msec.2016.09.005
47. Ivanov, I.T., Paarvanova, B.K., Ivanov, V., Smuda, K., Bäumler, H., Georgieva, R. Effects of heat and freeze on isolated erythrocyte submembrane skeletons. Gen Physiol Biophys. 2017;36(2):155-65 DOI: 10.4149/gpb_2016046
48. Ijad Kao, Yu Xiong, Axel Steffen, Kathrin Smuda, Lian Zhao, Radostina Georgieva, Hans Bäumler. Preclinical SAFETY investigations of submicron sized hemoglobin based oxygen carrier HBMP-700. Artificial Organs (2017) DOI:10.1111/aor.13071 (2018),42(5):549-559
49. Huiying Li, Yu Xiong, Yixian Zhang, Weijun Tong, Radostina Georgieva, Hans Bäumler, and Changyou Gao*. Photo-decomposable Submicrometer Albumin Particles Cross-linked by ortho-Nitrobenzyl Derivatives. Macromolecular Chemistry and Physics DOI:10.1002/macp.201700413
50. Yu Xiong, Radostina Georgieva, Axel Steffen, Kathrin Smuda, Hans Bäumler. Structure and Properties of Hybrid Biopolymer Particles Fabricated by Co-precipitation Cross-linking Dissolution Procedure. Journal of Colloid and Interface Science 514 (2018) 156–164 https://doi.org/10.1016/j.jcis.2017.12.030
51. Olga Baidukova, Quan Wang, Saranya Chaiwaree, Dorette Freyer, Ausanai Prapan, Radostina Georgieva, Lian Zhao, Hans Bäumler. Antioxidative Protection of Haemoglobin Microparticles (HbMPs) by polydopamine. J Artificial Cells, Nanomedicine and Biotechnology (2018) 46:sup3, S693-S701, https://doi.org/10.1080/21691401.2018.1505748
52. Chiraphat Kloypan, Aussanai Prapan, Nittiya Suwannason, Saranya Chaiwaree, Waraporn Kaewprayoon, Axel Steffen, Yu Xiong, Nuttakorn Baisaeng, Radostina Georgieva, Hans Bäumler. Improved Oxygen Storage Capacity of Haemoglobin Submicron Particles by One-Pot Formulation. J ARTIFICIAL CELLS, NANOMEDICINE, AND BIOTECHNOLOGY (2018), 46, NO. S3, S964–S972 https://doi.org/10.1080/21691401.2018.1521819
53. Changyou Gao, Yixian Zhang, Du Wang, Kathrin Smuda, Radostina Georgieva, Hans Bäumler. Inflammatory activation of human serum albumin- or ovalbumin-modified chitosan nanoparticles to macrophages and their immune response in human whole blood. Journal of Materials Chemistry B 6(26)3096-3106,          DOI: 10.1039/C7TB03096G
54. Chiraphat Kloypan, Nittiya Suwannasom, Saranya Chaiwaree, Ausanai Prapan, Kathrin Smuda, Nuttakorn Baisaeng, Axel Pruß, Radostina Georgieva, Hans Bäumler. In-vitro Haemocompatibility of Dextran-Protein Submicron Particles. J Artificial Cells, Nanomedicine and Biotechnology (2018) 47:1, 241-249, https://doi.org/10.1080/21691401.2018.1548476
55. Nittiya Suwannasom, Kathrin Smuda, Chiraphat Kloypan, Waraporn Kaewprayoon, Nuttakorn Baisaeng, Radostina Georgieva, Axel Pruss, Hans Bäumler. Detection of CD33 Expression on Monocyte Surface is influenced by phagocytosis and temperature. General Physiology and Biophysics (2019) 38:369-378 doi:10.4149/gpb_2019021 http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=GPB&file=2019_05_369.pdf
56. Nittiya Suwannasom, Kathrin Smuda, Chiraphat Kloypan, Waraporn Kaewprayoon, Nuttakorn Baisaeng, Ausanai Prapan, Saranya Chaiwaree, Radostina Georgieva and Hans Bäumler. Albumin Submicron Particles with Entrapped Riboflavin - Fabrication and Characterization. Nanomaterials 2019, 9(3),482 https://doi.org/10.3390/nano9030482
57. Ausanai Prapan, Nittiya Suwannasom, Chiraphat Kloypan, Saranya Chaiwaree, Axel Steffen, Yu Xiong, Ijad Kao, Axel Pruß, Radostina Georgieva, Hans Bäumler. Surface Modification of Hemoglobin Based Oxygen Carriers Reduces the Recognition by Haptoglobin, Immunoglobulin and Hemoglobin Antibodies. 2019, 9(7), 454, 1-16; https://doi.org/10.3390/coatings9070454
58. Nittiya Suwannasom, Ijad Kao, Axel Pruss, Radostina Georgieva, Hans Bäumler Riboflavin: The Health Benefits of a Forgotten Natural Vitamin.  International Journal of Molecular Sciences 21(3):950 DOI: 10.3390/ijms21030950
59. Saranya Chaiwaree, Ausanai Prapan, Nittiya Suwannasom, Tomás Laporte, Tanja Neumann, Axel Pruß, Radostina Georgieva and Hans Bäumler. Doxorubicin–Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake. Pharmaceutics 2020, 12(3), 224; https://doi.org/10.3390/pharmaceutics12030224
60. Hans Bäumler. Künstliche Sauerstofftransporter können mehr als Sauerstoff liefern - Artificial Oxygen Carriers Can Do More Than Just Deliver Oxygen. Transfusionsmedizin 2020; 10, 1-9.
61. Waraporn Kaewprayoon, Nittiya Suwannasom, Chiraphat Kloypan, Axel Steffen, Yu Xiong, Eyk Schellenberger, Axel Pruss, Radostina Georgieva, Hans Bäumler. Determination of methemoglobin in hemoglobin submicron particles using NMR relaxometry. International Journal of Molecular Sciences 2020, 21(23),8978; https://doi.org/10.3390/ijms21238978 
62. Kanyaluck Jantakee, Ausanai Prapan, Saranya Chaiwaree, Nittiya Suwannasom, Waraporn Kaewprayoon, Radostina Georgieva, Yingmanee Tragoolpua and Hans Bäumler. Fabrication and Characterization of Human Serum Albumin Particles Loaded with Non-sericin Extract Obtained from Silk Cocoon as a Carrier System for Hydrophobic Substances. Polymers 2021, 13(3), 334; doi:10.3390/polym13030334